The blood-brain barrier is a specialized system of endothelial cells that protects the brain from harmful substances in the blood and supplies the brain with required nutrients. The integrity of this barrier is important for maintaining the health of the brain but makes treating disorders in the CNS very difficult.
1. Why are most therapeutic drugs are unable to cross the blood brain barrier, and distinguish what strategies are being used to make penetration of the blood brain barrier possible.
2. What are some of the negative consequences that can occur when the blood brain barrier is weakened and distinguish some common causes of blood brain barrier injury.